Publications of the Weinhart group

PUBLICATIONS

A. Daneshgar, O. Klein, G. Nebrich, M. Weinhart, P. Tang, A. Arnold, I. Ullah, J. Pohl, S. Moosburner, N. Raschzok, B. Strücker, M. Bahra, J. Pratschke, I.M Sauer, K.H. Hillebrandt, The human liver matrisome–Proteomic analysis of native and fibrotic human liver extracellular matrices for organ engineering approaches, Biomaterials 2020, 257, 120247. DOI: 10.1016/j.biomaterials.2020.120247.

H. Everwien, E. Keshi, K.H. Hillebrandt, B. Ludwig, M. Weinhart, P. Tang, A.S. Beierle, H. Napierala, J. Gassner, N. Seiffert, S. Moosburner, D. Geisel, A. Reutzel-Selke, B. Strücker, J. Pratschke, N. Haep, I.M. Sauer, Engineering an endothelialized, endocrine Neo-Pancreas: evaluation of islet functionality in an ex vivo model, Acta Biomater. 2020, in press. DOI: 10.1016/j.actbio.2020.09.022.

D.D. Stöbener, M. Weinhart*, Thermoresponsive Poly (glycidyl ether) Brush Coatings on Various Tissue Culture Substrates—How Block Copolymer Design and Substrate Material Govern Self-Assembly and Phase Transition, Polymers, 2020, 12 (9), 1899. DOI: 10.3390/polym12091899.

L. Elomaa, E. Keshi, I. M. Sauer, M. Weinhart, Development of GelMA/PCL and dECM/PCL resins for 3D printing of acellular in vitro tissue scaffolds by stereolithography, Mater. Sci. Eng. C 2020, 112, 110958. DOI: 10.1016/j.msec.2020.110958.

A. Daneshgar, P. Tang, C. Remde, M. Lommel, S. Moosburner, U. Kertzscher, O. Klein, M. Weinhart, J. Pratschke, I. M. Sauer, K. H. Hillebrandt, Teburu-Open source 3D printable bioreactor for tissue slices as dynamic three-dimensional cell culture models, Artif. Organs 201943, 1035. DOI: 10.1111/aor.13518.

M. Weinhart, A. Hocke, S. Hippenstiel, J. Kurreck, S. Hedtrich, 3D organ models-Revolution in pharmacological research?, Pharmacol. Res. 2019139, 446. DOI: 10.1016/j.phrs.2018.11.002.

D. D. Stöbener, J. Scholz, U. Schedler, M. Weinhart, Switchable Oligo(glycidyl ether) Acrylate Bottlebrushes  "Grafted-from" Polystyrene Surfaces: A Versatile Strategy toward Functional Cell Culture Substrates, Biomacromolecules 201819, 4207. DOI: 10.1021/acs.biomac.8b00933.

D. D. Stöbener, A. Hoppensack, J. Scholz, M. Weinhart, Endothelial, smooth muscle and fibroblast cell sheet fabrication from self-assembled thermoresponsive poly(glycidyl ether) brushes, Soft Matter 201814, 8333. DOI: 10.1039/C8SM01099D.

T. Hiller, J. Berg, L. Elomaa, V. Röhrs, I. Ullah, K. Schaar, A.-C. Dietrich, M. A. Al-Zeer, A. Kurtz, A. C. Hocke, S. Hippenstiel, H. Fechner, M. Weinhart, J. Kurreck, Generation of a 3D Liver Model Comprising Human Extracellular Matrix in an Alginate/Gelatin-Based Bioink by Extrusion Bioprinting for Infection and Transduction Studies, Int. J. Mol. Sci. 201819, 3129. DOI: 10.3390/ijms19103129.

J. Berg, T. Hiller, M. S. Kissner, T. H. Qazi, G. N. Duda, A. C. Hocke, S. Hippenstiel, L. Elomaa, M. Weinhart, C. Fahrenson, J. Kurreck, Optimization of cell-laden bioinks for 3D bioprinting and efficient infection with influenza A virus, Sci. Rep. 20188, 13877. DOI: 10.1038/s41598-018-31880-x.

D. D. Stöbener, D. Donath, M. Weinhart, Fast and solvent-free microwave-assisted synthesis of thermoresponsive oligo(glycidyl ether)s, J. Polym. Sci. Polym. Chem. 201856, 2496. DOI: 10.1002/pola.29227.

S. Heinen, S. Rackow, J. L. Cuellar-Camacho, I. S. Donskyi, W. E. S. Unger, M. Weinhart, Transfer of functional thermoresponsive poly(glycidyl ether) coatings for cell sheet fabrication from gold to glass surfaces, J. Mater. Chem. B 20186, 1489. DOI: 10.1039/c7tb03263c.

N. Hadjesfandiari, M. Weinhart, J. N. Kizhakkedathu, R. Haag, D. E. Brooks, Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry, Adv. Healthc. Mater. 20187, 1700839. DOI: 10.1002/adhm.201700839.

D. D. Stöbener, M. Uckert, J. L. Cuellar-Camacho, A. Hoppensack, M. Weinhart, Ultrathin Poly(glycidyl ether) Coatings on Polystyrene for Temperature-Triggered Human Dermal Fibroblast Sheet Fabrication, ACS Biomater. Sci. Eng. 20173, 2155. DOI: 10.1021/acsbiomaterials.7b00270.

S. Heinen, J. L. Cuéllar-Camacho, M. Weinhart, Thermoresponsive poly(glycidyl ether) brushes on gold: Surface engineering parameters and their implication for cell sheet fabrication, Acta Biomater. 201759, 117. DOI: 10.1016/j.actbio.2017.06.029.

S. Heinen, M. Weinhart, Poly(glycidyl ether)-Based Monolayers on Gold Surfaces: Control of Grafting Density and Chain Conformation by Grafting Procedure, Surface Anchor, and Molecular Weight, Langmuir 201733, 2076. DOI: 10.1021/acs.langmuir.6b03927.

S. Heinen, S. Rackow, A. Schäfer, M. Weinhart, A Perfect Match: Fast and Truly Random Copolymerization of Glycidyl Ether Monomers to Thermoresponsive Copolymers, Macromolecules 201750, 44. DOI: 10.1021/acs.macromol.6b01904.

J. Wen, M. Weinhart, B. Lai, J. Kizhakkedathu, D. E. Brooks, Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol, Biomaterials 201686, 42. DOI:  10.1016/j.biomaterials.2016.01.067.

O. Wagner, J. Thiele, M. Weinhart, L. Mazutis, D. A. Weitz, W. T. S. Huck, R. Haag, Biocompatible fluorinated polyglycerols for droplet microfluidics as an alternative to PEG-based copolymer surfactants, Lab Chip 201616, 65. DOI: 10.1039/c5lc00823a.

D. Maysinger, D. Gröger, A. Lake, K. Licha, M. Weinhart, P. K.-Y. Chang, R. Mulvey, R. Haag, R. A. McKinney, Dendritic Polyglycerol Sulfate Inhibits Microglial Activation and Reduces Hippocampal CA1 Dendritic Spine Morphology Deficits, Biomacromolecules 201516, 3073. DOI: 10.1021/acs.biomac.5b00999.

T. Becherer, S. Heinen, Q. Wei, R. Haag, M. Weinhart, In-depth analysis of switchable glycerol based polymeric coatings for cell sheet engineering, Acta Biomater. 201525, 43. DOI: 10.1016/j.actbio.2015.06.036.

R. A. Shenoi, M. T. Kalathottukaren, R. J. Travers, B. F. L. Lai, A. L. Creagh, D. Lange, K. Yu, M. Weinhart, B. H. Chew, C. Du, D. E. Brooks, C. J. Carter, J. H. Morrissey, C. A. Haynes, J. N. Kizhakkedathu, Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants, Sci. Transl. Med. 20146, 260ra150. DOI: 10.1126/scitranslmed.3009427.

K. Oishi, Y. Hamaguchi, T. Matsushita, M. Hasegawa, N. Okiyama, J. Dernedde, M. Weinhart, R. Haag, T. F. Tedder, K. Takehara, H. Kohsaka, M. Fujimoto, A crucial role of L-selectin in C protein-induced experimental polymyositis in mice, Arthritis Rheumatol. 201466, 1864. DOI: 10.1002/art.38630.

D. Gröger, M. Kerschnitzki, M. Weinhart, S. Reimann, T. Schneider, B. Kohl, W. Wagermaier, G. Schulze-Tanzil, P. Fratzl, R. Haag, Selectivity in bone targeting with multivalent dendritic polyanion dye conjugates, Adv. Healthc. Mater. 20143, 375. DOI: 10.1002/adhm.201300205.

D. Gröger, F. Paulus, K. Licha, P. Welker, M. Weinhart, C. Holzhausen, L. Mundhenk, A. D. Gruber, U. Abram, R. Haag, Synthesis and biological evaluation of radio and dye labeled amino functionalized dendritic polyglycerol sulfates as multivalent anti-inflammatory compounds, Bioconjug. Chem. 201324, 1507. DOI: 10.1021/bc400047f.

M. Lange, S. Braune, K. Luetzow, K. Richau, N. Scharnagl, M. Weinhart, A. T. Neffe, F. Jung, R. Haag, A. Lendlein, Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity, Macromol. Rapid. Commun. 201233, 1487. DOI: 10.1002/marc.201200426.

K. Licha, P. Welker, M. Weinhart, N. Wegner, S. Kern, S. Reichert, I. Gemeinhardt, C. Weissbach, B. Ebert, R. Haag, M. Schirner, Fluorescence imaging with multifunctional polyglycerol sulfates: novel polymeric near-IR probes targeting inflammation, Bioconjug. Chem. 201122, 2453. DOI: 10.1021/bc2002727.

G. Gunkel, M. Weinhart, T. Becherer, R. Haag, W. T. S. Huck, Effect of polymer brush architecture on antibiofouling properties, Biomacromolecules 201112, 4169. DOI: 10.1021/bm200943m.

M. Weinhart, D. Gröger, S. Enders, J. Dernedde, R. Haag, Synthesis of dendritic polyglycerol anions and their efficiency toward L-selectin inhibition, Biomacromolecules 201112, 2502. DOI: 10.1021/bm200250f.

M. Weinhart, D. Gröger, S. Enders, S. B. Riese, J. Dernedde, R. K. Kainthan, D. E. Brooks, R. Haag, The role of dimension in multivalent binding events: structure-activity relationship of dendritic polyglycerol sulfate binding to L-selectin in correlation with size and surface charge density, Macromol. Biosci. 201111, 1088. DOI: 10.1002/mabi.201100051.

M. Weinhart, T. Becherer, N. Schnurbusch, K. Schwibbert, H.-J. Kunte, R. Haag, Linear and Hyperbranched Polyglycerol Derivatives as Excellent Bioinert Glass Coating Materials, Adv. Eng. Mater. 201113, B501. DOI: 10.1002/adem.201180012.

M. Weinhart, T. Becherer, R. Haag, Switchable, biocompatible surfaces based on glycerol copolymers, Chem. Commun. 201147, 1553. DOI: 10.1039/C0CC04002A.

M. Weber, A. Bujotzek, K. Andrae, M. Weinhart, R. Haag, Computational entropy estimation of linear polyether-modified surfaces and correlation with protein resistant properties of such surfaces, Mol. Simulat. 201137, 899. DOI: 10.1080/08927022.2011.566606.

J. Dernedde, A. Rausch, M. Weinhart, S. Enders, R. Tauber, K. Licha, M. Schirner, U. Zügel, A. von Bonin, R. Haag, Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation, Proc. Natl. Acad. Sci. USA 2010107, 19679. DOI: 10.1073/pnas.1003103107.

A. R. Abate, J. Thiele, M. Weinhart, D. A. Weitz, Patterning microfluidic device wettability using flow confinement, Lab Chip 201010, 1774. DOI: 10.1039/C004124F.

M. Weinhart, I. Grunwald, M. Wyszogrodzka, L. Gaetjen, A. Hartwig, R. Haag, Linear poly(methyl glycerol) and linear polyglycerol as potent protein and cell resistant alternatives to poly(ethylene glycol), Chem. Asian J. 20105, 1992. DOI: 10.1002/asia.201000127.

PATENTS AND PATENT APPLICATIONS

D. Stöbener, M. Weinhart, A Thermoresponsive Polymer and Its Use as a Cell Culture Support, 2016, EP16191842.0.

L. Yu, Q. Wei, R. Haag, M. Weinhart, Blockcopolymere als bionierte universelle Monoschichtsysteme, 2016, EP16177279.

M. Weinhart, J. Dernedde, R. Haag, Polyglycerolsulfat-Farbstoffkonjugate und Entzündungstargeting, 2016, DE102016212764

M. Weinhart, R.A. Shenoi, D. Gröger, B.F. Lai, D.E. Brooks, J.N. Kizhakkedathu, R. Haag, Anionic Linear Polyglycerol Derivatives, A Method for Manufacturing and Applications 2015, EP3048130A1, WO/2016/116489, PCT/EP2016/051097.

Q. Wei, T. Becherer, M. Weinhart, R. Haag, Bioinert article and its use, 2013, EP3044252A1, WO2015036364A1, PCT/EP2014/069091.

R. Haag, M. Weinhart, T. Becherer, W. Friess, S. Küchler, K. Höger, U. Schedler, Method for Producing Coated Glass Surfaces, 2013, DE102011081260A1, EP2744762A1, WO2013026795A1, PCT/EP2012/066094.

J. Dernedde, D. Gröger, R. Haag, J. Vonneman, M. Weinhart, Nanoparticles Functionalized with Dendritic Polyglycerol Sulphate, 2012,  DE102011101952A1, WO2012156094A1, PCT/EP2012/002136.

K. Licha, M. Schirner, P. Welker, R. Haag, M. Weinhart, F. Paulus, Polyanionc Multivalent Macromolecules for Intracellular Targeting of Proliferation and Protein Synthesis, 2010, US8877171B2, CA2788736A1, CN102781478A, EP2531221A1, US20130095035, WO2011095311A1, PCT/EP2011/000425.

R. Haag, J. Dernedde, R. Tauber, B. Gesche, S. Enders, M. Weinhart, Dendritic Polyglycerol Sulfates and Sulfonates and Their Use for Inflammatory Diseases, 2006, US20120328519A1, CA2659940A1, CN101506272A, CN102585202A, DE102006036326A1, EP2046868A2, US20140363507, WO2008015015A2, WO2008015015A3, PCT/EP2007/006889.

R. Haag, M. Wyszogrodzka, M. Weinhart, Production of Linear, Methylated Polyglycerol Derivatives for Functionalization of Surfaces in Medical Applications. 2006, DE102006027125, EP2044141A1, WO2007141248A1.